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Glycyrrhizin alleviates liver injury by precisely inhibiting the overactivation of this pathway in normal hepatocytes, which reverses cell cycle blockade and restores normal hepatocyte proliferation and function through downregulating p53/p21 and upregulating Cyclin D1, all without compromising the antitumor efficacy of gefitinib via the same pathway in cancer cells (Li et al., 2025)

They do this by mimicking the action of a naturally occurring hormone called GLP-1 that helps regulate blood sugar and reduce appetite